|
KMID : 0356719980140030655
|
|
Journal of the Korean Society of Coloproctology
1998 Volume.14 No. 3 p.655 ~ p.659
|
|
|
Small Flat Adenocarcinoma of the Colon Arising from Familial Adenomatous Polyposis Patient: Suggesting de novo Origin
|
|
Park Dong-Kook
Lee Min-Chul
Jun Ho-Jin
Lee Chan-Young
Kim Jung-Teak
Jung Min
Park Jong-Kweon
Ryu Jin-Woo
|
|
|
Abstract
|
|
|
|
Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells. Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.
|
|
|
KEYWORD
|
|
|
Small flat adenocarcinoma, Colon
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|